Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type	Study_count
Total_Studies	3605
interventional	2874
Observational	646
Registry	85

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug	1257
Drug\|placebo	423
Behavioral	313
Other	252
Device	169
Procedure	81
Dietary Supplement	65
Dietary Supplement\|placebo	48
Drug\|Other	33
Drug\|Procedure	27
Behavioral\|Other	25
Device\|Other	23
Device\|Drug	16
Diagnostic Test	16
Behavioral\|Drug	15
Behavioral\|Device	11
Device\|Procedure	10
Other\|placebo	8
Other\|Procedure	8
Drug\|Other\|placebo	6
Biological	5
Dietary Supplement\|Drug\|placebo	5
placebo	5
Radiation	5
Combination Product	4
Device\|Drug\|placebo	4
Device\|Drug\|Procedure	4
Biological\|placebo	3
Device\|Diagnostic Test	3
Device\|placebo	3
Dietary Supplement\|Other	3
Behavioral\|Procedure	2
Combination Product\|placebo	2
Dietary Supplement\|Drug	2
Behavioral\|Device\|Other	1
Behavioral\|Dietary Supplement	1
Behavioral\|Dietary Supplement\|Other	1
Behavioral\|Dietary Supplement\|placebo	1
Behavioral\|Drug\|placebo	1
Biological\|Diagnostic Test\|Drug\|placebo	1
Biological\|Diagnostic Test\|Other	1
Biological\|Drug	1
Biological\|Drug\|placebo	1
Biological\|Other	1
Dietary Supplement\|Drug\|Other	1
Dietary Supplement\|Drug\|Other\|placebo	1
Dietary Supplement\|Procedure	1
Drug\|Other\|placebo\|Procedure	1
Drug\|placebo\|Procedure	1
Drug\|Radiation	1
Genetic	1
Other\|Procedure\|Radiation	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country	Study_Count
United States	954
NA	311
Korea, Republic of	139
China	126
Japan	102
Brazil	82
Canada	79
Germany	75
United Kingdom	63
France	62
Spain	45
Switzerland	45
Denmark	32
India	23
Netherlands	21
Germany\|Switzerland	20
Austria	19
Taiwan	19
United States\|Germany	19
Egypt	17
Sweden	16
Italy	15
Turkey	15
Belgium	13
Norway	13
Mexico	12
United States\|Canada	12
Finland	11
Russian Federation	11
United States\|Puerto Rico	11
Greece	10
Australia	8
Israel	8
Cameroon	7
Ireland	7
Singapore	7
Thailand	7
Poland	6
South Africa	6
Pakistan	5
Peru	5
Portugal	5
Hong Kong	4
United States\|United Kingdom	4
Vietnam	4
Colombia	3
Ghana	3
Indonesia	3
Iran, Islamic Republic of	3
Lebanon	3
Malaysia	3
Nepal	3
Nigeria	3
Panama	3
Philippines	3
United States\|Germany\|Spain	3
Argentina	2
Australia\|New Zealand	2
Austria\|Germany	2
Bangladesh	2
Belgium\|Canada\|Denmark\|Finland\|France\|Korea, Republic of\|Netherlands\|Norway\|Philippines\|South Africa\|Sweden\|Taiwan	2
Belgium\|Canada\|France\|Italy\|Netherlands\|Spain	2
Chile	2
China\|Japan\|Korea, Republic of\|Taiwan\|Thailand	2
Czech Republic	2
Czechia	2
Denmark\|Finland\|France\|Germany\|Hong Kong\|Ireland\|Italy\|Korea, Republic of\|Malaysia\|Netherlands\|Norway\|South Africa\|Spain\|Sweden\|Switzerland\|Taiwan	2
Denmark\|Finland\|Norway\|Sweden	2
Germany\|Netherlands	2
Germany\|Netherlands\|United Kingdom	2
Germany\|United Kingdom	2
Hungary	2
Jordan	2
Kenya	2
Moldova, Republic of	2
Romania	2
Saudi Arabia	2
Slovenia	2
United States\|Argentina\|Australia\|Austria\|Brazil\|Canada\|Chile\|China\|Denmark\|France\|Germany\|Greece\|India\|Israel\|Italy\|Korea, Republic of\|Mexico\|Netherlands\|Poland\|Singapore\|Sweden\|Taiwan\|United Kingdom	2
United States\|Argentina\|Mexico	2
United States\|Australia\|Austria\|Belgium\|Canada\|Czech Republic\|France\|Germany\|Italy\|Netherlands\|Poland\|Spain\|United Kingdom	2
United States\|Australia\|Austria\|Belgium\|Canada\|France\|Germany\|Italy\|Netherlands\|Spain\|United Kingdom	2
United States\|Australia\|Canada	2
United States\|Austria\|Germany	2
United States\|Belgium\|Hungary\|Slovakia	2
United States\|Belgium\|Ireland	2
United States\|Canada\|Puerto Rico	2
United States\|Chile\|Mexico	2
United States\|Dominican Republic	2
United States\|France\|Germany\|Italy\|Netherlands\|Switzerland\|United Kingdom	2
United States\|Iceland	2
United States\|Israel	2
United States\|Russian Federation	2
NA	1
Algeria	1
Algeria\|Argentina\|Brazil\|Colombia\|Ecuador\|Egypt\|Guatemala\|Lebanon\|Mexico\|Morocco\|Panama\|Peru\|Saudi Arabia\|Tunisia\|United Arab Emirates\|Venezuela	1
Argentina\|Brazil\|Chile\|Mexico	1
Argentina\|Chile\|Ecuador\|Finland\|France\|Germany\|Italy\|Norway\|Spain\|Sweden\|Switzerland\|Turkey	1
Argentina\|Germany\|Norway\|Poland\|Slovakia\|Sweden\|Turkey	1
Armenia	1
Armenia\|Croatia\|Hungary\|Poland\|Russian Federation\|Serbia\|Slovenia	1
Australia\|Austria\|Belgium\|France\|Germany\|Netherlands\|New Zealand\|Switzerland	1
Australia\|Austria\|Bulgaria\|Czech Republic\|Ireland\|Italy\|New Zealand\|Russian Federation\|Slovakia\|Spain\|Switzerland\|Turkey\|Ukraine\|United Kingdom	1
Australia\|Austria\|Bulgaria\|Czech Republic\|Ireland\|Italy\|New Zealand\|Russian Federation\|Slovakia\|Spain\|Ukraine\|United Kingdom	1
Australia\|Belgium\|Czech Republic\|Denmark\|Italy	1
Australia\|Belgium\|Denmark\|France\|Germany\|Greece\|Ireland\|Italy\|Netherlands\|Spain\|Sweden\|United Kingdom	1
Australia\|Bulgaria\|Denmark\|Estonia\|Germany\|Hungary\|Israel\|Latvia\|Lithuania\|Slovakia\|United Kingdom	1
Australia\|Canada\|Czech Republic	1
Australia\|Czechia\|France\|Greece\|Pakistan\|Portugal\|Thailand\|United Kingdom	1
Australia\|Greece	1
Australia\|Poland	1
Austria\|Belgium\|Czechia\|France\|Germany\|Hungary\|Italy\|Latvia\|Poland\|Spain\|United Kingdom	1
Austria\|Belgium\|Czechia\|Hungary\|Latvia\|Lithuania\|Poland	1
Austria\|Belgium\|France\|Germany\|Hungary\|Italy\|Poland\|United Kingdom	1
Austria\|Belgium\|France\|Germany\|Italy\|Netherlands\|Portugal\|Switzerland\|United Kingdom	1
Austria\|Belgium\|Italy\|Portugal\|Switzerland\|United Kingdom	1
Austria\|Czechia\|Germany\|Poland	1
Austria\|France\|Germany\|Netherlands\|South Africa\|Spain\|Switzerland\|United Kingdom	1
Austria\|Germany\|Italy\|Netherlands\|Portugal\|Spain\|Switzerland\|United Kingdom	1
Bangladesh\|Pakistan\|Sri Lanka	1
Belarus\|France\|Ukraine	1
Belgium\|Brazil\|France\|Germany\|Guatemala\|Hungary\|Italy\|Lithuania\|Poland	1
Belgium\|Canada\|Czechia\|Egypt\|Germany\|Greece\|Hungary\|Israel\|Italy\|Netherlands\|South Africa\|Spain\|Turkey	1
Belgium\|China\|Czechia\|France\|Germany\|Hungary\|Korea, Republic of\|Lithuania\|Mexico\|Poland\|Russian Federation\|Switzerland\|Thailand\|Turkey\|Ukraine\|United Kingdom	1
Belgium\|China\|Czechia\|France\|Germany\|Hungary\|Lithuania\|Mexico\|Poland\|Russian Federation\|Switzerland\|Thailand\|Turkey\|Ukraine\|United Kingdom	1
Belgium\|Colombia\|Finland\|Germany\|Israel\|Italy\|Mexico\|Netherlands\|Norway\|Peru\|South Africa\|Spain\|Sweden	1
Belgium\|Czechia\|Germany\|Poland	1
Belgium\|Denmark\|Finland\|France\|Germany\|Ireland\|Italy\|Netherlands\|South Africa\|Spain	1
Belgium\|France\|Germany\|Italy\|Poland\|Ukraine	1
Belgium\|France\|Germany\|United Kingdom	1
Belgium\|France\|Italy\|Netherlands\|Poland\|Portugal\|Spain	1
Belgium\|Germany\|Greece\|Ireland\|Netherlands\|Poland\|United Kingdom	1
Belgium\|Germany\|Italy\|Luxembourg\|Netherlands\|New Zealand	1
Belgium\|Israel\|United Kingdom	1
Belgium\|Latvia\|Malta\|Romania\|Russian Federation\|Slovakia	1
Belgium\|Lithuania\|Poland	1
Belgium\|Netherlands\|United Kingdom	1
Bolivia	1
Brazil\|Canada\|Ecuador\|Germany\|Hungary\|Korea, Republic of\|Malaysia\|Mexico\|Panama\|Philippines\|Singapore\|Slovakia\|Spain\|Turkey\|United Kingdom\|Venezuela	1
Brazil\|Chile\|Colombia\|Egypt\|Lebanon\|Mexico\|Morocco\|Tunisia\|Venezuela	1
Brazil\|Colombia\|Guatemala\|Mexico\|Morocco\|Tunisia\|United Arab Emirates\|Venezuela	1
Brazil\|India\|Philippines	1
Bulgaria\|Czechia\|France\|Germany\|Poland\|Spain\|Ukraine	1
Bulgaria\|Estonia\|Finland\|Germany\|Netherlands\|Poland\|Russian Federation\|Serbia\|Slovakia\|Sweden	1
Bulgaria\|Israel	1
Canada\|Costa Rica\|France\|Germany\|Greece\|Guatemala\|South Africa\|Switzerland\|United Kingdom\|Venezuela	1
Canada\|Croatia	1
Canada\|Denmark\|France\|Germany\|Italy\|Norway\|Spain\|Sweden\|United Kingdom	1
Canada\|France\|Switzerland	1
Canada\|Germany\|Netherlands	1
Canada\|Germany\|Netherlands\|United States	1
Canada\|United Kingdom	1
Canada\|United Kingdom\|	1
Chile\|China\|Indonesia\|Korea, Republic of\|Mexico\|Philippines\|Taiwan\|Thailand	1
Chile\|Guatemala\|Hong Kong\|Argentina\|Australia\|Brazil\|India\|Indonesia\|Israel\|Jordan\|Korea, Republic of\|Kuwait\|Lebanon\|Malaysia\|Mexico\|Morocco\|Pakistan\|Peru\|Philippines\|Saudi Arabia\|Singapore\|South Africa\|Taiwan\|Thailand\|Tunisia\|Turkey\|United Arab Emirates\|	1
China\|Germany\|United Kingdom	1
China\|Greece\|Italy	1
China\|Hong Kong\|Japan\|Korea, Republic of\|Philippines\|Taiwan\|Thailand	1
China\|Hong Kong\|Korea, Republic of\|Philippines\|Singapore\|Taiwan\|Thailand	1
China\|India\|Thailand	1
China\|Japan\|Korea, Republic of\|Malaysia\|Philippines\|Taiwan	1
China\|Korea, Republic of	1
China\|Malaysia\|Philippines	1
China\|Taiwan\|Thailand	1
China\|Turkey	1
Colombia\|Ecuador	1
Colombia\|Ecuador\|Hong Kong\|Indonesia\|Malaysia\|Philippines\|Singapore\|Taiwan\|Thailand\|Turkey\|	1
Colombia\|Finland\|Germany\|Guatemala\|Korea, Republic of\|Philippines\|Poland\|Romania\|Russian Federation\|Singapore	1
Colombia\|Germany\|Hungary\|Italy\|Japan\|Mexico\|Poland\|Taiwan\|Turkey	1
Colombia\|Mexico	1
Costa Rica\|Croatia\|Czech Republic\|Dominican Republic\|Indonesia\|Jordan\|Korea, Republic of\|Kuwait\|Lebanon\|Malaysia\|Mexico\|Panama\|Philippines\|Russian Federation\|Saudi Arabia\|Taiwan\|Thailand\|Turkey\|United Arab Emirates\|Venezuela	1
Croatia	1
Czech Republic\|Finland\|France\|Germany\|Hungary\|Italy\|Poland\|Slovakia\|Spain\|Sweden	1
Czech Republic\|France\|Germany\|Hong Kong\|Korea, Republic of\|Netherlands\|Russian Federation\|Slovakia\|South Africa\|Sweden\|Taiwan\|Ukraine	1
Czech Republic\|France\|Germany\|Hungary\|Italy\|Lithuania\|Poland\|Portugal\|Serbia\|Sweden\|Switzerland\|Turkey	1
Czech Republic\|Germany\|Latvia\|Netherlands\|Poland\|Switzerland	1
Czech Republic\|Hungary\|Singapore\|United Kingdom	1
Czech Republic\|Italy\|New Zealand\|Spain	1
Czech Republic\|New Zealand	1
Czechia\|Poland	1
Denmark\|Finland\|Netherlands\|Norway\|Sweden\|United Kingdom	1
Ecuador	1
Egypt\|Hong Kong\|India\|Indonesia\|Korea, Republic of\|Malaysia\|Morocco\|Pakistan\|Philippines\|Singapore\|Taiwan\|Thailand\|Tunisia\|Vietnam	1
Estonia	1
Estonia\|France\|Iceland\|India\|Italy\|Korea, Republic of\|Lithuania\|Spain\|Venezuela	1
Estonia\|France\|Italy\|Norway\|Poland	1
Estonia\|Germany\|Spain	1
Ethiopia	1
Finland\|Germany	1
Finland\|Hungary\|Norway\|United Kingdom	1
Finland\|Sweden	1
France\|Bulgaria\|Estonia\|Germany\|Hungary\|Italy\|Lithuania\|Netherlands\|Poland\|Serbia\|Slovakia\|Spain\|Sweden\|United Kingdom	1
France\|Germany	1
France\|Germany\|Greece\|Italy\|Sweden	1
France\|Hungary\|Romania\|Slovakia	1
France\|Italy\|Korea, Republic of\|Poland\|Thailand	1
France\|Italy\|Spain	1
France\|Tunisia	1
Germany\|	1
Germany\|Australia\|Austria\|Belgium\|France\|Latvia\|Poland\|Spain\|Switzerland\|United Kingdom	1
Germany\|Belgium\|Czechia\|France\|Hungary\|Israel\|Italy\|Poland\|Spain\|United Kingdom	1
Germany\|Hungary\|Spain\|Switzerland	1
Germany\|Italy\|Mexico\|Netherlands\|Poland	1
Germany\|Netherlands\|Belgium\|Slovakia	1
Germany\|Netherlands\|Sweden	1
Germany\|Netherlands\|Switzerland	1
Germany\|Philippines\|Romania\|Russian Federation\|Singapore\|Spain	1
Germany\|Russian Federation\|United Kingdom	1
Germany\|Switzerland\|United Kingdom	1
Germany\|Ukraine	1
Germany\|United States\|Argentina\|Australia\|Austria\|Belarus\|Belgium\|Canada\|Chile\|China\|Colombia\|Czechia\|Denmark\|France\|Greece\|Hungary\|India\|Ireland\|Israel\|Korea, Republic of\|Malaysia\|Mexico\|Netherlands\|Peru\|Poland\|Romania\|Russian Federation\|Serbia\|Singapore\|Slovakia\|Spain\|Sweden\|Switzerland\|Taiwan\|Thailand\|Turkey\|Ukraine\|United Kingdom	1
Germany\|United States\|Greece\|Italy\|Netherlands\|United Kingdom	1
Greece\|Italy	1
Greece\|Netherlands	1
Greece\|Slovenia	1
Greece\|United Kingdom	1
Guatemala	1
Honduras\|Mexico	1
Hungary\|Croatia\|Georgia\|Serbia\|Slovenia	1
India\|Korea, Republic of\|Philippines\|Taiwan	1
Israel\|Serbia	1
Israel\|United States\|Belgium\|Canada\|France\|Germany\|Italy\|Netherlands\|Portugal\|Spain\|Sweden\|United Kingdom	1
Italy\|Spain	1
Italy\|Spain\|United Kingdom\|	1
Italy\|United States\|Brazil\|Chile\|Colombia\|Guatemala\|Hungary\|India\|Japan\|Malaysia\|Mexico\|Poland\|Russian Federation\|Sweden\|Taiwan	1
Italy\|Venezuela	1
Japan\|Korea, Republic of	1
Japan\|United States	1
Latvia	1
Lesotho	1
Lesotho\|Switzerland\|Tanzania	1
Netherlands\|Argentina\|Czech Republic\|Germany\|Iceland\|Italy\|Poland\|Slovakia	1
Netherlands\|Austria\|Belgium\|Bulgaria\|Czechia\|Denmark\|France\|Germany\|Poland\|Romania\|Russian Federation\|Slovakia\|Spain\|Ukraine	1
Netherlands\|Denmark\|Estonia\|Former Serbia and Montenegro\|France\|Germany\|Lithuania\|Poland\|Sweden\|Ukraine\|United Kingdom	1
Netherlands\|Spain	1
New Zealand	1
Portugal\|Austria\|Belgium\|Finland\|Greece\|Hungary\|Ireland\|Italy\|Slovenia\|Spain\|Switzerland\|	1
Slovakia	1
Slovakia\|Belgium\|Bulgaria\|Czechia\|Denmark\|Germany\|Hungary\|Italy\|Latvia\|Netherlands\|Poland\|Romania\|Russian Federation\|Spain\|Ukraine	1
Spain\|United States\|Australia\|Austria\|Belgium\|Canada\|France\|Germany\|Greece\|Italy\|Japan\|Netherlands\|Sweden\|United Kingdom	1
Taiwan\|Turkey\|United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Canada\|China\|Czech Republic\|Denmark\|France\|Germany\|Ireland\|Israel\|Italy\|Japan\|Korea, Republic of\|Mexico\|Netherlands\|Poland\|Portugal\|Russian Federation\|Slovakia\|Spain\|Switzerland\|United Kingdom	1
Tanzania	1
Tunisia	1
Turkey\|	1
United Kingdom\|Austria\|Germany\|Netherlands\|Poland	1
United States\|Argentina\|Australia\|Austria\|Belarus\|Belgium\|Bulgaria\|Canada\|Chile\|China\|Colombia\|Croatia\|Finland\|France\|Germany\|Hong Kong\|Hungary\|India\|Israel\|Italy\|Malaysia\|Mexico\|Netherlands\|Peru\|Poland\|Romania\|Russian Federation\|Serbia\|Singapore\|Slovakia\|South Africa\|Sweden\|Taiwan\|Thailand\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belarus\|Belgium\|Bulgaria\|Canada\|Chile\|China\|Colombia\|Croatia\|France\|Germany\|Hong Kong\|Hungary\|India\|Israel\|Italy\|Malaysia\|Mexico\|Netherlands\|Norway\|Peru\|Poland\|Romania\|Russian Federation\|Serbia\|Singapore\|Slovakia\|South Africa\|Spain\|Sweden\|Taiwan\|Thailand\|Turkey\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belarus\|Belgium\|Canada\|Chile\|China\|Colombia\|Czechia\|Denmark\|France\|Germany\|Greece\|Hungary\|India\|Ireland\|Israel\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|Netherlands\|Peru\|Poland\|Romania\|Russian Federation\|Serbia\|Singapore\|Slovakia\|Spain\|Sweden\|Switzerland\|Taiwan\|Thailand\|Turkey\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Canada\|China\|Czechia\|Denmark\|Germany\|Hungary\|Israel\|Italy\|Korea, Republic of\|Mexico\|Netherlands\|Poland\|Portugal\|Russian Federation\|Singapore\|Slovakia\|Spain\|Sweden\|Switzerland\|Taiwan\|Thailand\|Turkey\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Canada\|China\|Czech Republic\|Denmark\|France\|Germany\|Greece\|Ireland\|Israel\|Italy\|Japan\|Korea, Republic of\|Mexico\|Netherlands\|New Zealand\|Poland\|Portugal\|Russian Federation\|Singapore\|Spain\|Sweden\|Switzerland\|Taiwan\|Thailand\|Turkey\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Canada\|China\|Czechia\|Denmark\|France\|Germany\|Greece\|Italy\|Japan\|Korea, Republic of\|Mexico\|Poland\|Portugal\|Russian Federation\|Singapore\|Sweden\|Switzerland\|Taiwan\|Thailand\|Turkey\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Canada\|China\|Czechia\|Denmark\|France\|Germany\|Israel\|Italy\|Japan\|Korea, Republic of\|Mexico\|Poland\|Portugal\|Russian Federation\|Slovakia\|Spain\|Switzerland\|Taiwan\|Turkey\|United Kingdom	1
United States\|Argentina\|Australia\|Belgium\|Brazil\|Bulgaria\|Canada\|China\|Croatia\|Czechia\|Denmark\|France\|Greece\|Italy\|Korea, Republic of\|Poland\|Romania\|Spain\|Sweden\|Taiwan\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Belgium\|Brazil\|Bulgaria\|Canada\|China\|Croatia\|Czechia\|Denmark\|France\|Greece\|Italy\|Korea, Republic of\|Poland\|Romania\|Spain\|Taiwan\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Belgium\|Brazil\|Canada\|Czechia\|Germany\|Israel\|Japan\|Mexico\|Netherlands\|Philippines\|Spain\|United Kingdom	1
United States\|Argentina\|Australia\|Belgium\|Brazil\|Denmark\|France\|Germany\|New Zealand\|Spain	1
United States\|Argentina\|Australia\|Brazil\|Canada\|Chile\|Colombia\|Estonia\|Hungary\|Israel\|Jordan\|Netherlands\|New Zealand\|Poland\|United Kingdom	1
United States\|Argentina\|Australia\|Brazil\|Canada\|Chile\|Mexico\|Russian Federation\|Ukraine	1
United States\|Argentina\|Australia\|Canada\|Colombia\|Denmark\|Finland\|Greece\|Italy\|Mexico\|Panama\|Peru\|Romania\|Russian Federation\|South Africa\|Spain\|Sweden\|Taiwan	1
United States\|Argentina\|Australia\|Canada\|Korea, Republic of\|Mexico\|New Zealand\|Taiwan	1
United States\|Argentina\|Austria\|Belgium\|Brazil\|Canada\|Colombia\|Czechia\|Denmark\|Egypt\|France\|Germany\|Hong Kong\|Israel\|Italy\|Korea, Republic of\|New Zealand\|Peru\|Philippines\|Poland\|Russian Federation\|Singapore\|South Africa\|Spain\|Turkey\|United Kingdom	1
United States\|Argentina\|Belgium\|Brazil\|Canada\|Italy\|Korea, Republic of\|Lithuania\|Russian Federation\|South Africa\|Spain\|Ukraine\|United Kingdom	1
United States\|Argentina\|Brazil\|Bulgaria\|Colombia\|Hungary\|Italy\|Mexico\|Poland\|South Africa\|Turkey\|Ukraine	1
United States\|Argentina\|Brazil\|Canada\|Chile\|Germany\|Greece\|Hong Kong\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|Netherlands\|Poland\|Portugal\|Russian Federation\|Singapore\|South Africa\|Spain\|Taiwan\|Turkey	1
United States\|Argentina\|Brazil\|Canada\|Denmark\|France\|Germany\|Italy\|Spain\|Sweden\|United Kingdom	1
United States\|Argentina\|Brazil\|Chile\|Colombia\|India\|Kenya\|Peru\|South Africa\|Uganda\|Zambia	1
United States\|Argentina\|Brazil\|Mexico\|Peru\|Puerto Rico	1
United States\|Argentina\|Brazil\|Mexico\|South Africa	1
United States\|Argentina\|Canada\|Chile\|Mexico\|Peru	1
United States\|Argentina\|Canada\|Colombia\|Czechia\|Egypt\|Germany\|Italy\|Korea, Republic of\|Malaysia\|New Zealand\|Singapore\|South Africa\|Turkey\|United Kingdom	1
United States\|Argentina\|Canada\|Denmark\|Finland\|France\|Germany\|Hungary\|Italy\|Latvia\|Lithuania\|Netherlands\|Poland\|Russian Federation\|Slovakia\|Spain\|Sweden\|Taiwan	1
United States\|Argentina\|Canada\|Germany\|Romania\|Slovakia\|Spain\|Taiwan\|Vietnam	1
United States\|Argentina\|Canada\|Hungary\|India\|Korea, Republic of\|Romania\|Slovakia\|Spain	1
United States\|Argentina\|Colombia\|Finland\|Germany\|Italy\|Russian Federation\|Spain\|Sweden	1
United States\|Argentina\|Colombia\|France\|Germany\|Greece\|Italy\|Japan\|Korea, Republic of\|Russian Federation\|Spain\|Taiwan	1
United States\|Argentina\|Colombia\|France\|Germany\|India\|Spain	1
United States\|Argentina\|Ecuador\|Germany\|Guatemala\|Italy\|Switzerland\|Turkey	1
United States\|Argentina\|France\|Germany\|Hungary\|Italy\|Japan\|Russian Federation\|Spain	1
United States\|Argentina\|Guatemala\|Philippines\|Puerto Rico\|Russian Federation\|Spain	1
United States\|Argentina\|Korea, Republic of\|Mexico\|Netherlands\|Slovakia\|South Africa\|Spain\|Sweden	1
United States\|Argentina\|Mexico\|Peru	1
United States\|Australia	1
United States\|Australia\|Austria\|Belgium\|Brazil\|Denmark\|Hong Kong\|Hungary\|Israel\|Peru\|Philippines\|Poland\|Spain\|Taiwan	1
United States\|Australia\|Austria\|Belgium\|Canada\|China\|Czech Republic\|France\|Germany\|Italy\|Netherlands\|Spain\|Switzerland\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Canada\|China\|Czechia\|Denmark\|France\|Germany\|Italy\|Japan\|Netherlands\|Poland\|Singapore\|Spain\|Switzerland\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Canada\|Denmark\|France\|Germany\|Ireland\|Italy\|Netherlands\|Spain\|Sweden\|Switzerland\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Canada\|France\|Germany\|India\|Ireland\|Israel\|Italy\|Mexico\|Netherlands\|Poland\|Portugal\|Puerto Rico\|Spain\|Sweden\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Canada\|France\|Germany\|Ireland\|Israel\|Italy\|Netherlands\|Poland\|Spain\|United Kingdom	1
United States\|Australia\|Austria\|Canada\|China\|Colombia\|Finland\|France\|Hungary\|Israel\|Korea, Republic of\|Malaysia\|Mexico\|Philippines\|Poland\|Portugal\|Russian Federation\|South Africa\|Spain\|Thailand\|Ukraine\|Vietnam	1
United States\|Australia\|Austria\|Canada\|Germany\|Greece\|Ireland\|Japan\|United Kingdom	1
United States\|Australia\|Austria\|Canada\|Germany\|Greece\|Japan\|United Kingdom	1
United States\|Australia\|Belarus\|China\|Czechia\|France\|Germany\|Hungary\|India\|Israel\|Italy\|Mexico\|Netherlands\|Poland\|Russian Federation\|Serbia\|South Africa\|Spain\|Ukraine	1
United States\|Australia\|Belarus\|China\|Czechia\|France\|Germany\|Hungary\|India\|Israel\|Italy\|Mexico\|Poland\|Russian Federation\|Serbia\|South Africa\|Spain\|Ukraine	1
United States\|Australia\|Belgium\|Bosnia and Herzegovina\|Croatia\|Czechia\|Germany\|Greece\|Hong Kong\|Israel\|Latvia\|Malaysia\|Mexico\|Poland\|Romania\|Russian Federation\|Serbia\|Singapore\|South Africa\|Spain\|Thailand\|Turkey\|Ukraine	1
United States\|Australia\|Belgium\|Brazil\|Canada\|Germany\|Israel\|Philippines\|Singapore\|Spain	1
United States\|Australia\|Belgium\|Brazil\|Czech Republic\|Denmark\|France\|Germany\|Hong Kong\|Hungary\|Israel\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|Netherlands\|Norway\|Poland\|Singapore\|South Africa\|Spain\|Sweden\|United Kingdom	1
United States\|Australia\|Belgium\|Brazil\|Czech Republic\|Denmark\|France\|Germany\|Hong Kong\|Hungary\|Israel\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|Netherlands\|Poland\|Singapore\|South Africa\|Spain\|Sweden\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|China\|Czechia\|Denmark\|Finland\|France\|Germany\|Greece\|Hungary\|Israel\|Italy\|Korea, Republic of\|Lithuania\|Netherlands\|Poland\|Russian Federation\|Spain\|Ukraine\|United Kingdom	1
United States\|Australia\|Belgium\|France\|Germany\|Italy	1
United States\|Australia\|Belgium\|Germany\|Italy\|Lithuania\|United Kingdom	1
United States\|Australia\|Brazil\|Bulgaria\|Canada\|Czechia\|Germany\|Hungary\|Italy\|Japan\|Malaysia\|Mexico\|Poland\|Russian Federation\|South Africa\|Spain\|Taiwan\|Turkey	1
United States\|Australia\|Brazil\|Czech Republic\|Hungary	1
United States\|Australia\|Brazil\|France\|Germany\|Israel\|Spain\|United Kingdom	1
United States\|Australia\|Bulgaria\|Czechia\|Hungary\|Poland\|Romania\|Serbia\|Slovakia\|Spain	1
United States\|Australia\|Bulgaria\|Czechia\|Hungary\|Poland\|Romania\|Serbia\|Spain	1
United States\|Australia\|Canada\|Denmark\|Germany\|Israel\|Italy\|Latvia\|Lithuania\|Romania\|Sweden\|Turkey	1
United States\|Australia\|Canada\|Denmark\|Germany\|Israel\|New Zealand\|Philippines\|Poland\|Russian Federation\|United Kingdom	1
United States\|Australia\|Czech Republic\|France\|Germany\|Greece\|Israel\|Italy\|Taiwan\|United Kingdom	1
United States\|Australia\|Czech Republic\|Germany\|Hungary\|Israel\|Russian Federation\|Spain\|United Kingdom	1
United States\|Australia\|France\|Germany\|Hong Kong\|Israel\|Italy\|Malaysia\|Netherlands\|Russian Federation\|Singapore\|United Kingdom	1
United States\|Australia\|France\|New Zealand\|Spain	1
United States\|Austria\|Belgium\|Brazil\|Canada\|Czechia\|Denmark\|France\|Germany\|Greece\|Italy\|Japan\|Korea, Republic of\|Mexico\|Netherlands\|Poland\|Portugal\|Spain\|Taiwan\|Turkey\|United Kingdom	1
United States\|Austria\|Belgium\|Brazil\|France\|Germany\|Israel\|Italy\|Japan\|Mexico\|Netherlands\|Poland\|Spain\|Turkey	1
United States\|Austria\|Belgium\|Canada\|China\|France\|India\|Israel\|Italy\|Mexico\|Netherlands\|Poland\|Puerto Rico	1
United States\|Austria\|Belgium\|Canada\|Czechia\|France\|Germany\|Israel\|Italy\|Spain\|Switzerland	1
United States\|Austria\|Belgium\|Canada\|France\|Germany\|Italy\|Japan\|Korea, Republic of\|Netherlands\|Spain\|Sweden\|Switzerland\|United Kingdom	1
United States\|Austria\|Belgium\|France\|Germany\|Ireland\|Israel\|Italy\|Spain\|United Kingdom	1
United States\|Austria\|Bulgaria\|Chile\|China\|France\|Germany\|Greece\|Israel\|Malaysia\|Mexico\|Philippines\|Poland\|Portugal\|Romania\|Russian Federation\|Serbia\|Spain\|Turkey\|United Kingdom\|Vietnam	1
United States\|Austria\|Canada\|Germany	1
United States\|Austria\|Czech Republic\|Germany\|Italy\|New Zealand\|Poland\|Spain\|United Kingdom	1
United States\|Austria\|France\|Germany\|Ireland\|Norway\|Portugal\|Sweden\|Switzerland\|United Kingdom	1
United States\|Austria\|Germany\|United Kingdom	1
United States\|Belgium\|Brazil\|France\|Hungary\|India\|Italy\|Poland\|South Africa\|Sweden\|Turkey	1
United States\|Belgium\|Brazil\|France\|Hungary\|India\|Italy\|Poland\|South Africa\|Turkey	1
United States\|Belgium\|Brazil\|Hungary\|Poland	1
United States\|Belgium\|Canada\|Czech Republic\|Denmark\|France\|Israel\|Italy\|Netherlands\|Spain\|United Kingdom	1
United States\|Belgium\|Canada\|Czechia\|France\|Germany\|Italy\|Switzerland\|United Kingdom	1
United States\|Belgium\|Canada\|Denmark\|France\|Germany\|Italy\|Netherlands\|Norway\|Spain\|Sweden\|United Kingdom	1
United States\|Belgium\|Canada\|France\|Germany\|Ireland\|Italy\|Japan\|Spain\|United Kingdom	1
United States\|Belgium\|Canada\|Germany\|Italy\|Netherlands\|Peru\|Russian Federation\|Switzerland\|United Kingdom	1
United States\|Belgium\|Canada\|Germany\|Poland\|United Kingdom	1
United States\|Belgium\|Czech Republic\|Germany\|Ireland\|Romania	1
United States\|Belgium\|Czechia\|Germany\|Ireland\|Romania	1
United States\|Belgium\|Denmark\|Finland\|Germany\|Iceland\|India\|Switzerland	1
United States\|Belgium\|Denmark\|France\|Germany\|Italy\|Poland\|Puerto Rico\|Ukraine\|United Kingdom	1
United States\|Belgium\|Denmark\|France\|Italy\|Poland\|Russian Federation\|Singapore\|Spain\|Thailand	1
United States\|Belgium\|Egypt\|Germany\|Poland\|Slovakia\|Spain\|Turkey	1
United States\|Belgium\|France\|Germany\|Hungary\|India\|Italy\|Poland\|Slovakia\|Sweden\|Turkey	1
United States\|Belgium\|France\|Germany\|Hungary\|India\|Italy\|Poland\|Turkey	1
United States\|Belgium\|France\|Germany\|Ireland\|Netherlands\|Switzerland\|United Kingdom	1
United States\|Belgium\|France\|Germany\|Netherlands\|Poland\|United Kingdom	1
United States\|Belgium\|Germany\|Guatemala\|Hungary\|Poland\|Puerto Rico\|Slovakia\|Turkey	1
United States\|Belgium\|Germany\|Netherlands\|Spain\|United Kingdom	1
United States\|Belgium\|Romania\|Spain\|Sweden\|Switzerland\|Ukraine	1
United States\|Brazil\|Canada\|Chile\|Colombia\|Guatemala\|Hungary\|India\|Italy\|Japan\|Malaysia\|Mexico\|Peru\|Poland\|Russian Federation\|Sweden\|Taiwan	1
United States\|Brazil\|Czech Republic\|Denmark\|Germany\|Greece\|Portugal\|Saudi Arabia\|Slovakia\|Spain\|Sweden\|United Kingdom	1
United States\|Brazil\|Czechia\|France\|Germany\|Spain\|United Kingdom	1
United States\|Bulgaria\|China\|France\|Georgia\|Korea, Republic of\|Romania\|Russian Federation	1
United States\|Bulgaria\|Croatia\|Georgia\|Germany\|Hungary\|South Africa\|Ukraine\|United Kingdom	1
United States\|Bulgaria\|Czech Republic\|France\|Hungary\|Korea, Republic of\|Romania\|Russian Federation\|Slovakia\|Spain\|Ukraine	1
United States\|Bulgaria\|Czech Republic\|Hungary	1
United States\|Bulgaria\|Czechia\|Denmark\|France\|Germany\|Hungary\|Ireland\|Italy\|Poland\|South Africa\|Sweden\|United Kingdom	1
United States\|Canada\|Chile\|Ecuador\|Mexico\|Peru\|Spain	1
United States\|Canada\|Colombia\|Czech Republic\|Denmark\|Finland\|Germany\|Hungary\|India\|Mexico\|Peru\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Spain	1
United States\|Canada\|Denmark\|France\|Germany\|Greece\|Italy\|Netherlands\|Romania\|Russian Federation\|Spain\|United Kingdom	1
United States\|Canada\|France\|Germany\|Italy\|Netherlands\|Spain\|United Kingdom	1
United States\|Canada\|France\|Germany\|Russian Federation	1
United States\|Canada\|France\|Poland\|Spain\|United Kingdom	1
United States\|Canada\|Israel\|Puerto Rico	1
United States\|Canada\|Italy\|Puerto Rico\|Slovakia\|Spain\|Taiwan	1
United States\|Canada\|Netherlands	1
United States\|Chile\|Mexico\|Peru	1
United States\|Chile\|Mexico\|Peru\|Russian Federation	1
United States\|China	1
United States\|Czechia\|Russian Federation	1
United States\|Denmark\|France\|Germany\|Netherlands\|Switzerland	1
United States\|Dominican Republic\|India\|Russian Federation\|South Africa	1
United States\|Estonia\|Germany\|Spain	1
United States\|France\|Germany	1
United States\|France\|Germany\|Netherlands\|United Kingdom	1
United States\|France\|Italy	1
United States\|France\|Netherlands\|Spain\|United Kingdom	1
United States\|France\|Spain\|Switzerland	1
United States\|Germany\|Australia\|Canada\|Colombia\|Czech Republic\|Denmark\|Finland\|Hungary\|India\|Ireland\|Mexico\|Poland\|Puerto Rico\|Romania\|United Kingdom	1
United States\|Germany\|Belgium\|Canada\|France\|Israel\|Netherlands\|Russian Federation	1
United States\|Germany\|Netherlands	1
United States\|Greece\|Russian Federation	1
United States\|Guatemala\|Hungary\|Poland\|Puerto Rico\|Slovakia\|Turkey	1
United States\|Hong Kong\|Korea, Republic of\|Singapore\|Taiwan	1
United States\|India	1
United States\|India\|Russian Federation	1
United States\|Portugal	1
United States\|Singapore	1
United States\|Spain\|United Kingdom	1
Venezuela	1

Sites per Study

Site_count	Study_Count
1	1935
2	176
3	81
4	49
5	40
6	29
7	30
8	36
9	27
10	25
11	17
12	22
13	17
14	11
15	18
16	17
17	14
18	12
19	5
20	8
21	7
22	6
23	5
24	8
25	7
26	7
27	5
28	4
29	6
30	9
31	5
32	5
33	3
34	7
35	3
36	5
37	3
38	7
39	4
40	6
41	7
42	1
43	6
44	4
45	3
46	6
47	5
48	5
50	5
51	3
52	2
53	4
54	4
55	3
56	1
57	3
58	2
59	4
60	2
61	1
62	2
63	2
64	2
65	4
67	1
68	2
69	2
72	3
73	3
74	2
75	5
76	1
77	1
78	3
79	2
80	2
81	2
82	1
83	2
85	1
86	1
87	1
88	2
90	3
91	1
92	4
93	1
94	1
95	1
96	1
97	2
98	1
99	3
100	1
102	3
106	2
108	1
111	1
113	3
115	1
117	1
118	1
119	2
120	1
121	1
122	1
125	1
126	2
128	1
129	1
130	1
131	2
133	1
134	2
135	1
136	1
137	1
139	1
141	1
143	1
146	1
147	1
151	1
152	1
153	1
155	1
157	2
158	1
176	1
177	1
178	1
182	2
232	1
246	1
270	1
298	1
329	1
384	1
413	1

Phase

Phase	Study_Count
N/A	997
Phase 3	628
Phase 4	547
Phase 2	374
Phase 1	219
Phase 1/Phase 2	50
Phase 2/Phase 3	43
Early Phase 1	16

Number of Arms

Number_of_Arms	Count_of_Studies
1	486
2	1384
3	327
4	165
5	44
6	42
7	11
8	12
9	6
10	3
11	1
12	1
14	2
15	1
16	2
24	1
NA	386

Number of Updates

Count of Versions	Count of Studies
1	290
2	420
3	355
4	291
5	301
6	259
7	197
8	130
9	109
10	83
11	73
12	39
13	25
14	34
15	17
16	23
17	22
18	17
19	12
20	12
21	4
22	5
23	14
24	15
25	12
26	10
27	12
28	8
29	4
30	3
31	4
32	6
33	5
34	2
35	4
36	6
37	1
38	1
40	1
42	2
43	1
46	3
47	1
49	2
50	3
51	1
53	3
54	1
55	3
56	1
58	2
63	1
64	2
65	1
66	2
68	1
71	1
72	2
76	2
79	1
80	1
82	1
87	1
88	4
94	1
99	1
116	1
119	1
178	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	17954	2584	6.948142
Contacts/Locations	8270	2160	3.828704
Recruitment Status	3962	2218	1.786294
Study Design	3004	1939	1.549252
None (earliest Version on record)	2874	2874	1.000000
Outcome Measures	2480	1396	1.776504
Arms	1851	1148	1.612369
Interventions	1851	1148	1.612369
Eligibility	1843	1060	1.738679
Study Description	1754	953	1.840504
Sponsor/Collaborators	1690	1175	1.438298
Study Identification	1614	986	1.636917
Oversight	965	755	1.278146
More Information	779	376	2.071808
References	746	450	1.657778
Results	573	573	1.000000
Conditions	466	354	1.316384
IPDSharing	295	273	1.080586
Baseline Characteristics	251	208	1.206731
Reported Adverse Events	185	157	1.178344
Participant Flow	165	147	1.122449
Results Submission Events	143	143	1.000000
Documents	93	83	1.120482

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	5.00	2.0000	2.00000	6.00	3.000	12.0000	2.0000	2.000
1st Qu.	10.00	38.0000	24.00000	23.25	32.000	39.0000	129.0000	50.000
Median	24.50	83.0000	34.00000	57.50	70.000	80.0000	288.0000	124.000
Mean	188.50	638.9768	55.37788	104.24	125.325	307.0465	484.4587	556.757
3rd Qu.	104.25	238.0000	60.00000	106.75	136.000	248.0000	600.7500	360.000
Max.	1545.00	66570.0000	500.00000	1000.00	1659.000	4000.0000	13500.0000	40000.000

Trial Group Type

group_type	Group_Count
Experimental	3018
Active Comparator	1504
Placebo Comparator	559
NA	386
No Intervention	350
Other	246
Sham Comparator	69

Intervention Model

intervention_model	Study_Count
Parallel Assignment	1795
Single Group Assignment	598
Crossover Assignment	357
Factorial Assignment	68
NA	37
Sequential Assignment	19

Primary Purpose

primary_purpose	Study_Count
Treatment	2138
Prevention	238
Diagnostic	101
Health Services Research	96
NA	75
Basic Science	71
Other	69
Supportive Care	60
Screening	22
Device Feasibility	2
Educational/Counseling/Training	2

Observational Studies

Studies by Country

Country	Study_Count
United States	150
NA	132
China	30
France	27
Canada	24
Korea, Republic of	21
Germany	20
United Kingdom	15
Japan	14
Austria	13
Switzerland	13
Denmark	12
Italy	9
Russian Federation	9
Spain	9
Poland	8
Greece	7
Netherlands	7
Taiwan	7
Egypt	6
Hong Kong	6
Turkey	6
Belgium	5
Israel	5
Sweden	5
South Africa	4
Brazil	3
India	3
Mexico	3
Nigeria	3
Portugal	3
Romania	3
Thailand	3
United States\|Puerto Rico	3
Argentina	2
Egypt\|Saudi Arabia\|United Arab Emirates	2
Finland	2
Norway	2
Uganda	2
Algeria	1
Algeria\|Egypt\|Lebanon\|Saudi Arabia\|United Arab Emirates	1
Argentina\|Australia\|Austria\|Belgium\|Canada\|Colombia\|Czechia\|Denmark\|Estonia\|Finland\|France\|Germany\|Greece\|Ireland\|Italy\|Luxembourg\|Netherlands\|Norway\|Portugal\|Russian Federation\|Saudi Arabia\|Slovakia\|Spain\|Sweden\|Switzerland\|Taiwan\|Turkey\|United Kingdom	1
Armenia\|Austria\|Belgium\|Bulgaria\|Croatia\|Czechia\|Estonia\|Germany\|Greece\|Israel\|Italy\|Lebanon\|Lithuania\|Netherlands\|Poland\|Portugal\|Romania\|Serbia\|Spain\|Sweden\|Ukraine\|United Kingdom	1
Australia	1
Australia\|Austria\|Finland\|France\|Germany\|Greece\|Italy\|Netherlands\|New Zealand\|Norway\|Spain\|Sweden\|United Kingdom	1
Austria\|Belgium\|France\|Germany\|Greece\|Norway\|Russian Federation\|Spain\|Sweden\|Switzerland\|Turkey\|United Kingdom	1
Austria\|Germany\|Greece\|Italy\|Spain\|Switzerland\|United Kingdom	1
Austria\|Germany\|Switzerland	1
Bahrain\|Egypt\|Jordan\|Lebanon\|Morocco\|Oman\|Pakistan\|Qatar\|Russian Federation\|Saudi Arabia\|United Arab Emirates	1
Belgium\|Canada\|Colombia\|Czechia\|Ecuador\|Indonesia\|Jordan\|Lebanon\|Mexico\|Turkey\|Venezuela\|Yemen	1
Belgium\|Canada\|Colombia\|Germany\|Japan\|Sweden\|Turkey	1
Belgium\|Estonia\|Italy\|Portugal\|Spain\|United Kingdom	1
Belgium\|Germany\|Ireland\|Italy\|Switzerland	1
Colombia	1
Croatia	1
Croatia\|Czech Republic	1
Croatia\|Poland\|Slovakia\|Slovenia	1
Czech Republic	1
Czechia	1
Ecuador	1
France\|Italy\|Netherlands\|United Kingdom	1
Germany\|Ireland	1
Germany\|Netherlands	1
Germany\|Switzerland	1
Kazakhstan\|Kyrgyzstan\|Lebanon\|Russian Federation\|Saudi Arabia\|Turkey	1
Kazakhstan\|Russian Federation	1
Kyrgyzstan	1
Latvia	1
Malaysia	1
Mali	1
Poland\|Slovakia	1
Romania\|Slovakia	1
Serbia	1
Singapore	1
Slovakia	1
Slovenia	1
Spain\|Portugal\|France\|Germany\|Italy\|United Kingdom	1
Tunisia	1
United States\|Brazil	1
United States\|Canada	1
United States\|Canada\|Chile\|Ecuador\|Mexico\|Peru\|Spain	1
United States\|Canada\|Ireland\|United Kingdom	1
United States\|Canada\|Israel\|Singapore\|United Kingdom	1
United States\|Guatemala\|Hungary\|Poland\|Puerto Rico\|Slovakia\|Turkey	1
United States\|Iceland	1
United States\|Russian Federation	1
Vietnam	1

Sites per Study

Site_count	Study_Count
1	512
2	35
3	9
4	6
5	3
6	4
7	7
8	7
9	1
10	3
11	2
12	4
13	4
15	1
16	1
17	1
18	1
19	1
20	1
21	1
23	3
24	1
25	2
28	1
35	2
39	1
43	1
45	1
46	1
49	1
51	1
52	1
54	1
55	1
56	1
66	1
84	1
88	1
106	1
120	2
132	1
134	1
158	1
167	1
182	1
254	1
314	1
326	1
375	1
436	1
568	1
778	1
915	1
936	1
1300	1
1387	1
2389	1

Number of Updates

Count of Versions	Count of Studies
1	100
2	112
3	126
4	78
5	54
6	33
7	23
8	13
9	12
10	6
11	10
12	10
13	2
14	2
15	7
16	5
17	4
18	2
19	2
20	1
22	1
24	1
25	2
26	2
27	4
30	2
32	2
33	2
34	2
35	3
37	1
38	1
39	2
49	1
50	2
51	2
52	2
53	1
57	1
58	1
60	1
63	1
73	1
74	1
75	1
128	1
141	1
152	1
180	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	4127	546	7.558608
Contacts/Locations	1002	391	2.562660
None (earliest Version on record)	646	646	1.000000
Study Design	612	374	1.636364
Study Description	607	180	3.372222
Recruitment Status	603	390	1.546154
Eligibility	351	222	1.581081
Outcome Measures	325	210	1.547619
Study Identification	291	205	1.419512
Sponsor/Collaborators	261	205	1.273171
Groups	192	130	1.476923
Interventions	192	130	1.476923
Oversight	151	129	1.170543
References	120	76	1.578947
Conditions	84	61	1.377049
Results	75	75	1.000000
More Information	69	36	1.916667
IPDSharing	40	39	1.025641
Baseline Characteristics	25	21	1.190476
Reported Adverse Events	21	15	1.400000
Results Submission Events	14	14	1.000000
Documents	13	13	1.000000
Participant Flow	12	9	1.333333

Enrollment Metrics

Measure	Observational
Min	1.000
1st Qu	78.000
Median	254.000
Mean	8776.203
3rd Qu	1531.500
Max	1400000.000

Observation Model

observational_model	Study_Count
Cohort	339
NA	99
Case-Only	69
Case-Control	43
Other	37
Case Control	36
Case-Crossover	8
Ecologic or Community	8
Family-Based	2
Natural History	2
Case Control, Natural History	1
Defined Population	1
Defined Population, Natural History	1

Time Perspective

time_perspective	Study_Count
Prospective	410
Cross-Sectional	89
Retrospective	78
NA	55
Other	9
Cross-Sectional, Prospective	2
Longitudinal, Prospective	2
Cross-Sectional, Retrospective	1

Registries

Studies by Country

Country	Study_Count
United States	10
China	9
Korea, Republic of	6
NA	6
Poland	5
Brazil	4
Italy	4
Kyrgyzstan	4
Germany	3
Netherlands	3
Spain	3
Turkey	3
United States\|Puerto Rico	3
Denmark	2
Thailand	2
Argentina\|Armenia\|Australia\|Italy\|Kazakhstan\|Mexico\|Portugal\|Romania\|Russian Federation\|Ukraine	1
Austria	1
Belgium\|Netherlands\|Poland	1
Canada	1
Denmark\|Norway\|Sweden	1
Germany\|Netherlands	1
Greece	1
Hong Kong	1
Israel	1
Russian Federation	1
South Africa	1
Switzerland	1
Taiwan	1
Tunisia	1
Ukraine	1
United States\|Australia\|Austria\|Belgium\|Brazil\|Canada\|Denmark\|Egypt\|Finland\|Germany\|Italy\|Japan\|Korea, Republic of\|Netherlands\|Poland\|Russian Federation\|Slovakia\|Spain\|Switzerland\|Taiwan\|Turkey\|United Kingdom	1
United States\|Australia\|Brazil\|Canada\|China\|Colombia\|France\|Germany\|Hungary\|Israel\|Italy\|Japan\|Mexico\|Netherlands\|Poland\|Saudi Arabia\|Sweden\|Switzerland	1
United States\|Canada	1

Sites per Study

Site_count	Study_Count
1	63
2	3
3	1
4	1
5	1
6	1
8	2
11	1
17	1
19	1
24	1
32	1
38	1
44	1
51	1
52	2
59	1
70	1
76	1

Number of Updates

Count of Versions	Count of Studies
1	23
2	18
3	10
4	10
5	5
6	4
7	2
8	2
9	3
10	1
11	5
12	1
14	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	241	62	3.887097
Contacts/Locations	113	44	2.568182
None (earliest Version on record)	85	85	1.000000
Recruitment Status	57	40	1.425000
Study Design	45	35	1.285714
Outcome Measures	27	22	1.227273
Eligibility	22	17	1.294118
Study Description	22	20	1.100000
Groups	15	13	1.153846
Interventions	15	13	1.153846
Sponsor/Collaborators	13	12	1.083333
Study Identification	11	10	1.100000
Conditions	9	8	1.125000
Oversight	8	7	1.142857
IPDSharing	7	6	1.166667
References	7	7	1.000000
Documents	3	2	1.500000
Results	3	3	1.000000
More Information	2	2	1.000000

Enrollment Metrics

Measure	Registries
Min	10.000
1st Qu	146.000
Median	400.000
Mean	4794.859
3rd Qu	1371.000
Max	200000.000

Registry Model

observational_model	Study_Count
Cohort	60
Case-Control	11
Case-Only	7
Other	5
Case-Crossover	1
Case Control	1

Time Perspective

time_perspective	Study_Count
Prospective	65
Cross-Sectional	15
Other	4
NA	1

Follow-up

target_duration	Study_Count
5 Years	16
3 Years	10
2 Years	7
10 Years	6
6 Months	5
1 Day	4
4 Years	4
1 Year	3
12 Months	3
20 Years	3
3 Days	3
4 Weeks	3
2 Days	2
2 Weeks	2
4 Months	2
7 Days	2
1 Week	1
10 Months	1
12 Weeks	1
18 Months	1
2 Months	1
3 Months	1
36 Months	1
60 Days	1
7 Years	1
78 Weeks	1

intervention_type	Study_Count
Drug	1257
Drug\|placebo	423
Behavioral	313
Other	252
Device	169
Procedure	81
Dietary Supplement	65
Dietary Supplement\|placebo	48
Drug\|Other	33
Drug\|Procedure	27
Behavioral\|Other	25
Device\|Other	23
Device\|Drug	16
Diagnostic Test	16
Behavioral\|Drug	15
Behavioral\|Device	11
Device\|Procedure	10
Other\|placebo	8
Other\|Procedure	8
Drug\|Other\|placebo	6
Biological	5
Dietary Supplement\|Drug\|placebo	5
placebo	5
Radiation	5
Combination Product	4
Device\|Drug\|placebo	4
Device\|Drug\|Procedure	4
Biological\|placebo	3
Device\|Diagnostic Test	3
Device\|placebo	3
Dietary Supplement\|Other	3
Behavioral\|Procedure	2
Combination Product\|placebo	2
Dietary Supplement\|Drug	2
Behavioral\|Device\|Other	1
Behavioral\|Dietary Supplement	1
Behavioral\|Dietary Supplement\|Other	1
Behavioral\|Dietary Supplement\|placebo	1
Behavioral\|Drug\|placebo	1
Biological\|Diagnostic Test\|Drug\|placebo	1
Biological\|Diagnostic Test\|Other	1
Biological\|Drug	1
Biological\|Drug\|placebo	1
Biological\|Other	1
Dietary Supplement\|Drug\|Other	1
Dietary Supplement\|Drug\|Other\|placebo	1
Dietary Supplement\|Procedure	1
Drug\|Other\|placebo\|Procedure	1
Drug\|placebo\|Procedure	1
Drug\|Radiation	1
Genetic	1
Other\|Procedure\|Radiation	1

Count of Versions	Count of Studies
1	290
2	420
3	355
4	291
5	301
6	259
7	197
8	130
9	109
10	83
11	73
12	39
13	25
14	34
15	17
16	23
17	22
18	17
19	12
20	12
21	4
22	5
23	14
24	15
25	12
26	10
27	12
28	8
29	4
30	3
31	4
32	6
33	5
34	2
35	4
36	6
37	1
38	1
40	1
42	2
43	1
46	3
47	1
49	2
50	3
51	1
53	3
54	1
55	3
56	1
58	2
63	1
64	2
65	1
66	2
68	1
71	1
72	2
76	2
79	1
80	1
82	1
87	1
88	4
94	1
99	1
116	1
119	1
178	1

Count of Versions	Count of Studies
1	100
2	112
3	126
4	78
5	54
6	33
7	23
8	13
9	12
10	6
11	10
12	10
13	2
14	2
15	7
16	5
17	4
18	2
19	2
20	1
22	1
24	1
25	2
26	2
27	4
30	2
32	2
33	2
34	2
35	3
37	1
38	1
39	2
49	1
50	2
51	2
52	2
53	1
57	1
58	1
60	1
63	1
73	1
74	1
75	1
128	1
141	1
152	1
180	1

Count of Versions	Count of Studies
1	290
2	420
3	355
4	291
5	301
6	259
7	197
8	130
9	109
10	83
11	73
12	39
13	25
14	34
15	17
16	23
17	22
18	17
19	12
20	12
21	4
22	5
23	14
24	15
25	12
26	10
27	12
28	8
29	4
30	3
31	4
32	6
33	5
34	2
35	4
36	6
37	1
38	1
40	1
42	2
43	1
46	3
47	1
49	2
50	3
51	1
53	3
54	1
55	3
56	1
58	2
63	1
64	2
65	1
66	2
68	1
71	1
72	2
76	2
79	1
80	1
82	1
87	1
88	4
94	1
99	1
116	1
119	1
178	1

Count of Versions	Count of Studies
1	100
2	112
3	126
4	78
5	54
6	33
7	23
8	13
9	12
10	6
11	10
12	10
13	2
14	2
15	7
16	5
17	4
18	2
19	2
20	1
22	1
24	1
25	2
26	2
27	4
30	2
32	2
33	2
34	2
35	3
37	1
38	1
39	2
49	1
50	2
51	2
52	2
53	1
57	1
58	1
60	1
63	1
73	1
74	1
75	1
128	1
141	1
152	1
180	1

hypertension

Study Counts

Studies over Time

Interventional Trials

Intervention Type

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Studies by Country

Sites per Study

Phase

Number of Arms

Number of Updates

Update History Change Type

Enrollment Metrics by Phase

Trial Group Type

Intervention Model

Primary Purpose

Observational Studies

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Observation Model

Time Perspective

Registries

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Registry Model

Time Perspective

Follow-up

Count of Versions	Count of Studies
1	290
2	420
3	355
4	291
5	301
6	259
7	197
8	130
9	109
10	83
11	73
12	39
13	25
14	34
15	17
16	23
17	22
18	17
19	12
20	12
21	4
22	5
23	14
24	15
25	12
26	10
27	12
28	8
29	4
30	3
31	4
32	6
33	5
34	2
35	4
36	6
37	1
38	1
40	1
42	2
43	1
46	3
47	1
49	2
50	3
51	1
53	3
54	1
55	3
56	1
58	2
63	1
64	2
65	1
66	2
68	1
71	1
72	2
76	2
79	1
80	1
82	1
87	1
88	4
94	1
99	1
116	1
119	1
178	1

Count of Versions	Count of Studies
1	100
2	112
3	126
4	78
5	54
6	33
7	23
8	13
9	12
10	6
11	10
12	10
13	2
14	2
15	7
16	5
17	4
18	2
19	2
20	1
22	1
24	1
25	2
26	2
27	4
30	2
32	2
33	2
34	2
35	3
37	1
38	1
39	2
49	1
50	2
51	2
52	2
53	1
57	1
58	1
60	1
63	1
73	1
74	1
75	1
128	1
141	1
152	1
180	1